Pro-B-Type natriuretic peptide: a novel, specific biomarker for detection of left ventricular dysfunction in the general community
نویسندگان
چکیده
Background Pro-B-Type Natriuretic Peptide (ProBNP), from which biologically active BNP and inactive amino-terminal BNP (NT-proBNP) are processed, has recently been reported to be elevated in patients with heart failure (HF). It remains to be shown in a large cohort study whether ProBNP circulates in normals, what factors influence ProBNP, and whether or not it is a sensitive biomarker for left ventricular (LV) dysfunction.
منابع مشابه
Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide in the general community: determinants and detection of left ventricular dysfunction.
OBJECTIVES This study sought to characterize factors influencing amino-terminal pro-B-type natriuretic peptide (NT-proBNP) and to evaluate the ability of NT-proBNP to detect left ventricular (LV) dysfunction in a large community sample. BACKGROUND Secretion of BNP increases in cardiac disease, making BNP an attractive biomarker. Amino-terminal proBNP, a fragment of the BNP prohormone, is a ne...
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